Agave Gueingola is associated with cacti and succulents. The species name guiengola refers to the Cerro Guiengola, the mountain where the species was first discovered. Agave guiengola reach a diameter of 30–40 centimetres (12–16 in).
The leaves are thick, broad, whitish-green to bluish-colored, ovate to lanceolate, irregularly arranged, about 57 centimetres (22 in) long and 13–15 centimetres (5.1–5.9 in) wide. The dark brown margins of the leaves are densely toothed.
The year-old slender inflorescence is 2–3 metres (6 ft 7 in–9 ft 10 in)high. The pale yellow to white colored flowers are 33–35 millimetres (1.3–1.4 in) long and appear in clumps near the base.
The fruits are elongated, brown capsules 22–24 millimetres (0.87–0.94 in) long. The flowering period extends from February to March.